产品名称
NUD11 Rabbit Polyclonal Antibody
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
https://www.uniprot.org/uniprot/55190
Human Swissprot No.
Q96G61
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q96G61/entry
Mouse Gene Link
https://www.uniprot.org/uniprot/102954
Mouse Swissprot No.
P0C028
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P0C028
免疫原
Synthesized peptide derived from human NUD11 AA range: 83-133
特异性
This antibody detects endogenous levels of NUD11 at Human/Mouse
宿主
Polyclonal, Rabbit,IgG
背景介绍
NUDT11 belongs to a subgroup of phosphohydrolases that preferentially attack diphosphoinositol polyphosphates (Hidaka et al., 2002 [PubMed 12105228]).[supplied by OMIM, Mar 2008],
组织表达
Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is also expressed in pancreas and weakly expressed in thymus, prostate, ovary, lung, small intestine and heart.
功能
catalytic activity:Diphospho-myo-inositol polyphosphate + H(2)O = myo-inositol polyphosphate + phosphate.,cofactor:Magnesium or manganese. Manganese may be the true cofactor in vivo.,function:Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyzes the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.,similarity:Belongs to the Nudix hydrolase family. DIPP subfamily.,tissue specificity:Mainly expressed in testis and, at lower level in brain. According to PubMed:12121577, it is also expressed in pancreas and weakly expressed in thymus, prostate, ovary, lung, small intestine and heart.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
