产品名称
NUP85 Rabbit Polyclonal Antibody
蛋白名称
Nuclear pore complex protein Nup85 (85 kDa nucleoporin) (FROUNT) (Nucleoporin Nup75) (Nucleoporin Nup85) (Pericentrin-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79902
Human Swissprot No.
Q9BW27
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BW27
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=445007
Mouse Swissprot No.
Q8R480
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8R480/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=287830
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q4QQS8/entry
特异性
This antibody detects endogenous levels of NUP85 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus, nuclear pore complex . Chromosome, centromere, kinetochore . Cytoplasm, cytoskeleton, spindle . Cytoplasm . Nucleus membrane . During mitosis, localizes to the kinetochores and spindle poles (PubMed:12718872, PubMed:16807356). Upon CCl2 stimulation translocates from the cytoplasm to the membrane and colocalizes with CCR2 at the front of migrating cells (PubMed:15995708). .
功能
Essential component of the nuclear pore complex (NPC) that seems to be required for NPC assembly and maintenance . As part of the NPC Nup107-160 subcomplex plays a role in RNA export and in tethering NUP96/Nup98 and NUP153 to the nucleus . The Nup107-160 complex seems to be required for spindle assembly during mitosis . NUP85 is required for membrane clustering of CCL2-activated CCR2 . Seems to be involved in CCR2-mediated chemotaxis of monocytes and may link activated CCR2 to the phosphatidyl-inositol 3-kinase-Rac-lammellipodium protrusion cascade . Involved in nephrogenesis .
