产品名称
AUP1 Rabbit Polyclonal Antibody
蛋白名称
Ancient ubiquitous protein 1
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=550
Human Swissprot No.
Q9Y679
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9Y679
Mouse Swissprot No.
P70295
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P70295/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=680423
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/A1L134/entry
特异性
This antibody detects endogenous levels of AUP1 at Human,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Detected in blood platelets and leukocytes (at protein level). Ubiquitous. Highly expressed in placenta, liver, kidney, skeletal muscle, heart and brain.
细胞定位
Endoplasmic reticulum membrane ; Peripheral membrane protein . Lipid droplet .; Cytoplasmic vesicle, autophagosome . (Microbial infection) Upon Dengue virus infection, relocates from lipid droplets to autophagosomes. .
功能
Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome . Plays a role in lipid droplet formation . Induces lipid droplet clustering . Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation . Also required for the degradation of INSIG1, SREBF1 and SREBF2 . Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB . ; (Microbial infection) Following Dengue virus infection, required for induction of lipophagy which facilitates production of virus progeny particles.
