产品名称
TMEM98 Rabbit Polyclonal Antibody
基因名称
TMEM98 UNQ536/PRO1079
蛋白名称
Transmembrane protein 98 (Protein TADA1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26022
Human Swissprot No.
Q9Y2Y6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9Y2Y6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=103743
Mouse Swissprot No.
Q91X86
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91X86/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=303356
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6AYS5/entry
特异性
This antibody detects endogenous levels of TMEM98 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed with high expression in the ovary, pancreas and prostate (PubMed:25946230). Expressed in the eye, particularly in corneal endothelium, iris, ciliary body, sclera, optic nerve, optic nerve head, and retina (PubMed:24852644). Expressed by activated peripheral blood mononuclear cells (PubMed:25946230).
细胞定位
Cell membrane ; Single-pass type II membrane protein . Secreted . Secreted, extracellular exosome . Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Secreted by exosomes through a non-classical pathway. .
功能
Functions as a negative regulator of MYRF in oligodendrocyte differentiation and myelination. Interacts with the C-terminal of MYRF inhibiting MYRF self-cleavage and N-fragment nuclear translocation. The secreted form promotes differentiation of T helper 1 cells (Th1).
