产品名称
RBM39 Rabbit Polyclonal Antibody
蛋白名称
RNA-binding protein 39 (Hepatocellular carcinoma protein 1) (RNA-binding motif protein 39) (RNA-binding region-containing protein 2) (Splicing factor HCC1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9584
Human Swissprot No.
Q14498
Human Swissprot Link
https://www.uniprot.org/uniprot/Q14498
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=170791
Mouse Swissprot No.
Q8VH51
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VH51/entry
特异性
This antibody detects endogenous levels of RBM39 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed. Highly expressed in pancreas, skeletal muscle, lung and brain (PubMed:8227358). Expressed at intermediate level in kidney, liver and heart (PubMed:8227358).
细胞定位
Nucleus speckle . Concentrated in nuclear speckles (PubMed:8227358). Colocalizes with the core spliceosomal snRNP proteins (PubMed:8227358). .
功能
RNA-binding protein that acts as a pre-mRNA splicing factor . Acts by promoting exon inclusion via regulation of exon cassette splicing . Also acts as a transcriptional coactivator for steroid nuclear receptors ESR1/ER-alpha and ESR2/ER-beta, and JUN/AP-1, independently of the pre-mRNA splicing factor activity (By similarity).
