产品名称
KCC2/SLC12A5 Rabbit Polyclonal Antibody
基因名称
SLC12A5 KCC2 KIAA1176
蛋白名称
Solute carrier family 12 member 5 (Electroneutral potassium-chloride cotransporter 2) (K-Cl cotransporter 2) (hKCC2) (Neuronal K-Cl cotransporter)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57468
Human Swissprot No.
Q9H2X9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9H2X9
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57138
Mouse Swissprot No.
Q91V14
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91V14/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=171373
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q63633/entry
特异性
This antibody detects endogenous levels of KCC2/SLC12A5 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Brain specific. Detected in neuronal cells.
细胞定位
Membrane; Multi-pass membrane protein.
功能
Mediates electroneutral potassium-chloride cotransport in mature neurons and is required for neuronal Cl(-) homeostasis. As major extruder of intracellular chloride, it establishes the low neuronal Cl(-) levels required for chloride influx after binding of GABA-A and glycine to their receptors, with subsequent hyperpolarization and neuronal inhibition (By similarity). Involved in the regulation of dendritic spine formation and maturation .
