产品名称
AHI1 Rabbit Polyclonal Antibody
蛋白名称
Jouberin (Abelson helper integration site 1 protein homolog) (AHI-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54806
Human Swissprot No.
Q8N157
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8N157
Mouse Swissprot No.
Q8K3E5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K3E5/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=308923
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6DTM3/entry
特异性
This antibody detects endogenous levels of AHI1 at Human,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in the most primitive normal hematopoietic cells. Expressed in brain, particularly in neurons that give rise to the crossing axons of the corticospinal tract and superior cerebellar peduncles. Expressed in kidney (renal collecting duct cells) (at protein level).
细胞定位
Cytoplasm, cytoskeleton, cilium basal body . Cell junction, adherens junction . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . In the retinal photoreceptor cell layer, localizes at the connecting cilium. .
功能
Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development .
