产品名称
CNOT3 Rabbit Polyclonal Antibody
基因名称
CNOT3 KIAA0691 LENG2 NOT3
蛋白名称
CCR4-NOT transcription complex subunit 3 (CCR4-associated factor 3) (Leukocyte receptor cluster member 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4849
Human Swissprot No.
O75175
Human Swissprot Link
https://www.uniprot.org/uniprot/O75175
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=232791
Mouse Swissprot No.
Q8K0V4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8K0V4/entry
特异性
This antibody detects endogenous levels of CNOT3 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, lung and peripheral blood leukocytes.
细胞定位
Cytoplasm . Nucleus . Cytoplasm, P-body . NANOS2 promotes its localization to P-body. .
功能
Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.
