产品名称
PREB Rabbit Polyclonal Antibody
蛋白名称
Prolactin regulatory element-binding protein (Mammalian guanine nucleotide exchange factor mSec12)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10113
Human Swissprot No.
Q9HCU5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9HCU5
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=50907
Mouse Swissprot No.
Q9WUQ2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WUQ2/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=58842
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WTV0/entry
特异性
This antibody detects endogenous levels of PREB at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Endoplasmic reticulum membrane ; Single-pass membrane protein . Nucleus . Concentrates at endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). .
功能
Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER. ; Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription.
