产品名称
NRDE2 Rabbit Polyclonal Antibody
蛋白名称
UPF0614 protein C14orf102
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55051
Human Swissprot No.
Q9H7Z3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9H7Z3
Mouse Swissprot No.
Q80XC6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80XC6/entry
特异性
This antibody detects endogenous levels of NRDE2 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus speckle . Nucleus, nucleolus . Nucleus, nucleoplasm . Nucleus .
功能
Protein of the nuclear speckles that regulates RNA degradation and export from the nucleus through its interaction with MTREX an essential factor directing various RNAs to exosomal degradation . Changes the conformation of MTREX, precluding its association with the nuclear exosome and interaction with proteins required for its function in RNA exosomal degradation . Negatively regulates, for instance, the degradation of mRNAs and lncRNAs by inhibiting their MTREX-mediated recruitment to nuclear exosome . By preventing the degradation of RNAs in the nucleus, it promotes their export to the cytoplasm . U5 snRNP-associated RNA splicing factor which is required for efficient splicing of CEP131 pre-mRNA and plays an important role in centrosome maturation, integrity and function during mitosis . Suppresses intron retention in a subset of pre-mRNAs containing short, GC-rich introns with relatively weak 5' and 3' splice sites . Plays a role in DNA damage response .
