产品名称
AKAP7 Rabbit Polyclonal Antibody
蛋白名称
A-kinase anchor protein 7 isoforms alpha and beta (AKAP-7 isoforms alpha and beta) (A-kinase anchor protein 18 kDa) (AKAP 18) (Protein kinase A-anchoring protein 7 isoforms alpha/beta) (PRKA7 isoforms alpha/beta)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9465
Human Swissprot No.
O43687
Human Swissprot Link
https://www.uniprot.org/uniprot/O43687
Mouse Swissprot No.
O55074
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O55074/entry
特异性
This antibody detects endogenous levels of AKAP7 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in brain, heart, lung, pancreas and skeletal muscle.
细胞定位
[Isoform Alpha]: Lateral cell membrane; Lipid-anchor. Targeted predominantly to the lateral membrane.; [Isoform Beta]: Apical cell membrane; Lipid-anchor. Targeted predominantly to the apical membrane.
功能
Targets the cAMP-dependent protein kinase (PKA) to the plasma membrane, and permits functional coupling to the L-type calcium channel. The membrane-associated form reduces epithelial sodium channel (ENaC) activity, whereas the free cytoplasmic form may negatively regulate ENaC channel feedback inhibition by intracellular sodium.
