产品名称
Nav1.5 Rabbit Polyclonal Antibody
蛋白名称
Sodium channel protein type 5 subunit alpha (HH1) (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6331
Human Swissprot No.
Q14524
Human Swissprot Link
https://www.uniprot.org/uniprot/Q14524
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=20271
Mouse Swissprot No.
Q9JJV9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JJV9/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25665
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P15389/entry
特异性
This antibody detects endogenous levels of Nav1.5 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Found in jejunal circular smooth muscle cells (at protein level). Expressed in human atrial and ventricular cardiac muscle but not in adult skeletal muscle, brain, myometrium, liver, or spleen. Isoform 4 is expressed in brain.
细胞定位
Cell membrane ; Multi-pass membrane protein . Cytoplasm, perinuclear region . Cell membrane, sarcolemma, T-tubule . RANGRF promotes trafficking to the cell membrane. .
功能
This protein mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient . It is a tetrodotoxin-resistant Na(+) channel isoform . This channel is responsible for the initial upstroke of the action potential. Channel inactivation is regulated by intracellular calcium levels .
