产品名称
OFD1 Rabbit Polyclonal Antibody
蛋白名称
Oral-facial-digital syndrome 1 protein (Protein 71-7A)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=8481
Human Swissprot No.
O75665
Human Swissprot Link
https://www.uniprot.org/uniprot/O75665
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=237222
Mouse Swissprot No.
Q80Z25
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80Z25/entry
特异性
This antibody detects endogenous levels of OFD1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed. Expressed in 9 and 14 weeks old embryos in metanephric mesenchyme, oral mucosa, lung, heart, nasal and cranial cartilage, and brain. Expressed in metanephros, brain, tongue, and limb.
细胞定位
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, cilium basal body . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite . Localizes to centriole distal ends and to centriolar satellites (PubMed:20230748, PubMed:24121310). Localization to centrioles and pericentriolar satellites may be mediated by KIAA0753/OFIP (PubMed:26643951). .
功能
Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the centriolar satellites is removed by autophagy, which is an important step in the ciliogenesis regulation (By similarity).
