产品名称
RGS2 Rabbit Polyclonal Antibody
蛋白名称
Regulator of G-protein signaling 2 (RGS2) (Cell growth-inhibiting gene 31 protein) (G0/G1 switch regulatory protein 8)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5997
Human Swissprot No.
P41220
Human Swissprot Link
https://www.uniprot.org/uniprot/P41220
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19735
Mouse Swissprot No.
O08849
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O08849/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84583
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JHX0/entry
特异性
This antibody detects endogenous levels of RGS2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in acute myelogenous leukemia (AML) and in acute lymphoblastic leukemia (ALL).
细胞定位
[Isoform 1]: Cell membrane . Cytoplasm . Nucleus, nucleolus .; [Isoform 2]: Cell membrane . Cytoplasm . Nucleus, nucleolus .; [Isoform 3]: Cell membrane . Cytoplasm . Nucleus, nucleolus .; [Isoform 4]: Cell membrane . Mitochondrion .
功能
Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form . It is involved in the negative regulation of the angiotensin-activated signaling pathway . Plays a role in the regulation of blood pressure in response to signaling via G protein-coupled receptors and GNAQ. Plays a role in regulating the constriction and relaxation of vascular smooth muscle (By similarity). Binds EIF2B5 and blocks its activity, thereby inhibiting the translation of mRNA into protein .
