产品名称
LASS2 Rabbit Polyclonal Antibody
蛋白名称
Ceramide synthase 2 (CerS2) (LAG1 longevity assurance homolog 2) (SP260) (Tumor metastasis-suppressor gene 1 protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29956
Human Swissprot No.
Q96G23
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96G23
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=76893
Mouse Swissprot No.
Q924Z4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q924Z4/entry
特异性
This antibody detects endogenous levels of LASS2 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in kidney, liver, brain, heart, placenta and lung.
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein .
功能
Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very-long-chain fatty acyl-CoA (chain length C22-C27) . N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively (By similarity) . Plays a non-redundant role in the synthesis of ceramides with very-long-chain fatty acids in kidney, liver and brain. Regulates the abundance of myelin-specific sphingolipids galactosylceramide and sulfatide that affects myelin sheath architecture and motor neuron functions (By similarity).
