产品名称
RbAp46 Rabbit Polyclonal Antibody
蛋白名称
Histone-binding protein RBBP7 (Histone acetyltransferase type B subunit 2) (Nucleosome-remodeling factor subunit RBAP46) (Retinoblastoma-binding protein 7) (RBBP-7) (Retinoblastoma-binding protein p46)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=5931
Human Swissprot No.
Q16576
Human Swissprot Link
https://www.uniprot.org/uniprot/Q16576
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=245688
Mouse Swissprot No.
Q60973
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q60973/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83712
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q71UF4/entry
特异性
This antibody detects endogenous levels of RbAp46 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
功能
Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex.
