产品名称
VPS41 Rabbit Polyclonal Antibody
蛋白名称
Vacuolar protein sorting-associated protein 41 homolog (S53)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27072
Human Swissprot No.
P49754
Human Swissprot Link
https://www.uniprot.org/uniprot/P49754
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=218035
Mouse Swissprot No.
Q5KU39
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q5KU39/entry
特异性
This antibody detects endogenous levels of VPS41 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in cerebral cortex and cerebellum. Highly expressed in Purkinje cells.
细胞定位
Endosome membrane ; Peripheral membrane protein . Late endosome membrane ; Peripheral membrane protein . Early endosome membrane ; Peripheral membrane protein . Lysosome membrane ; Peripheral membrane protein . Golgi apparatus, trans-Golgi network . Cytoplasmic vesicle, clathrin-coated vesicle . Cytoplasm, cytosol .; (Microbial infection) Sequestrated at the late endosome by SARS coronavirus-2/SARS-CoV-2 ORF3A protein. .
功能
Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act in part as a core component of the putative HOPS endosomal tethering complex is proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes . Involved in homotypic vesicle fusions between late endosomes and in heterotypic fusions between late endosomes and lysosomes implicated in degradation of endocytosed cargo . Required for fusion of autophagosomes with lysosomes . Links the HOPS complex to endosomal Rab7 via its association with RILP and to lysosomal membranes via its association with ARL8B, suggesting that these interactions may bring the compartments to close proximity for fusion . Involved in the direct trans-Golgi network to late endosomes transport of lysosomal membrane proteins independently of HOPS . Involved in sorting to the regulated secretory pathway presumably implicating the AP-3 adapter complex (By similarity). May play a role in HOPS-independent function in the regulated secretory pathway .
