产品名称
TRIM22 Rabbit Polyclonal Antibody
蛋白名称
E3 ubiquitin-protein ligase TRIM22 (EC 6.3.2.-) (50 kDa-stimulated trans-acting factor) (RING finger protein 94) (Staf-50) (Tripartite motif-containing protein 22)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10346
Human Swissprot No.
Q8IYM9
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8IYM9
特异性
This antibody detects endogenous levels of TRIM22 at Human
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Strongly expressed in peripheral blood leukocytes, spleen, thymus, and ovary. Expressed at basal levels in other tissues.
细胞定位
Cytoplasm . Nucleus . Nucleus speckle. Nucleus, Cajal body. Localizes predominantly to the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies.
功能
Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity.
