产品名称
PLVAP Rabbit Polyclonal Antibody
蛋白名称
Plasmalemma vesicle-associated protein (Fenestrated endothelial-linked structure protein) (Plasmalemma vesicle protein 1) (PV-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83483
Human Swissprot No.
Q9BX97
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BX97
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=84094
Mouse Swissprot No.
Q91VC4
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91VC4/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56765
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WV78/entry
特异性
This antibody detects endogenous levels of PLVAP at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in lung, kidney, heart, aorta, placenta, muscle, pituitary gland, adrenals, mammary gland, bladder, lymph node, bone marrow, trachea, digestive tract, liver and tumor-associated endothelium.
细胞定位
Cell membrane ; Single-pass type II membrane protein . Membrane, caveola ; Single-pass type II membrane protein . Cytoplasm, perinuclear region . Membrane-associated protein of caveolae. Found in fenestral and stomatal diaphragms in fenestrated endothelia and transendothelial channels. Also colocalized with CAV1 in perinuclear region. .
功能
Endothelial cell-specific membrane protein involved in the formation of the diaphragms that bridge endothelial fenestrae. It is also required for the formation of stomata of caveolae and transendothelial channels. Functions in microvascular permeability, endothelial fenestrae contributing to the passage of water and solutes and regulating transcellular versus paracellular flow in different organs. Plays a specific role in embryonic development.
