产品名称
XLF Rabbit Polyclonal Antibody
蛋白名称
Non-homologous end-joining factor 1 (Protein cernunnos) (XRCC4-like factor)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79840
Human Swissprot No.
Q9H9Q4
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9H9Q4
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=75570
Mouse Swissprot No.
Q3KNJ2
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3KNJ2/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=363251
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6AYI4/entry
特异性
This antibody detects endogenous levels of XLF at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed.
细胞定位
Nucleus . Chromosome . Localizes to site of double-strand breaks; recruitment is dependent on XRCC5-XRCC6 (Ku) heterodimer. .
功能
DNA repair protein involved in DNA non-homologous end joining (NHEJ); required for double-strand break (DSB) repair and V(D)J recombination . Plays a key role in NHEJ by promoting the ligation of various mismatched and non-cohesive ends . Together with PAXX, collaborates with DNA polymerase lambda (POLL) to promote joining of non-cohesive DNA ends . May act in concert with XRCC5-XRCC6 (Ku) to stimulate XRCC4-mediated joining of blunt ends and several types of mismatched ends that are non-complementary or partially complementary . Associates with XRCC4 to form alternating helical filaments that bridge DNA and act like a bandage, holding together the broken DNA until it is repaired . The XRCC4-NHEJ1/XLF subcomplex binds to the DNA fragments of a DSB in a highly diffusive manner and robustly bridges two independent DNA molecules, holding the broken DNA fragments in close proximity to one other . The mobility of the bridges ensures that the ends remain accessible for further processing by other repair factors . Binds DNA in a length-dependent manner .
