产品名称
iASPP Rabbit Polyclonal Antibody
基因名称
PPP1R13L IASPP NKIP1 PPP1R13BL RAI
蛋白名称
RelA-associated inhibitor (Inhibitor of ASPP protein) (Protein iASPP) (NFkB-interacting protein 1) (PPP1R13B-like protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10848
Human Swissprot No.
Q8WUF5
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8WUF5
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=333654
Mouse Swissprot No.
Q5I1X5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q5I1X5/entry
特异性
This antibody detects endogenous levels of iASPP at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in heart, placenta and prostate. Weakly expressed in brain, liver, skeletal muscle, testis and peripheral blood leukocyte.
细胞定位
Cytoplasm . Nucleus . Predominantly cytoplasmic but also nuclear. .
功能
Regulator that plays a central role in regulation of apoptosis and transcription via its interaction with NF-kappa-B and p53/TP53 proteins. Blocks transcription of HIV-1 virus by inhibiting the action of both NF-kappa-B and SP1. Also inhibits p53/TP53 function, possibly by preventing the association between p53/TP53 and ASPP1 or ASPP2, and therefore suppressing the subsequent activation of apoptosis .
