产品名称
CPLX2 Rabbit Polyclonal Antibody
蛋白名称
Complexin-2 (Complexin II) (CPX II) (Synaphin-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10814
Human Swissprot No.
Q6PUV4
Human Swissprot Link
https://www.uniprot.org/uniprot/Q6PUV4
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=12890
Mouse Swissprot No.
P84086
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P84086/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=116657
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P84087/entry
特异性
This antibody detects endogenous levels of CPLX2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia.
细胞定位
Cytoplasm, cytosol . Cell junction, synapse, presynapse . Nucleus . Perikaryon . Translocated from the perikaryon to the presynaptic terminals during maturation of neuronal cells. In mast cells, cytosol and nucleus. Becomes enriched near plasma membrane following stimulation. .
功能
Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity).
