产品名称
UBXD1 Rabbit Polyclonal Antibody
蛋白名称
UBX domain-containing protein 6 (UBX domain-containing protein 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=80700
Human Swissprot No.
Q9BZV1
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BZV1
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=66530
Mouse Swissprot No.
Q99PL6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q99PL6/entry
特异性
This antibody detects endogenous levels of UBXD1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Enhanced expression in testis.
细胞定位
Cytoplasm . Cytoplasm, cytosol . Membrane ; Peripheral membrane protein . Nucleus . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Early endosome membrane ; Peripheral membrane protein . Late endosome membrane ; Peripheral membrane protein . Lysosome membrane ; Peripheral membrane protein . Localizes at the centrosome both in interphase and during mitosis (PubMed:18656546). May be recruited to endosomal and lysosomal membranes as part of a ternary complex with CAV1 and VCP (PubMed:21822278). Recruited to damaged lysosomes decorated with K48-linked ubiquitin chains (PubMed:27753622). .
功能
May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes . As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation . It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins . Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes .
