产品名称
TEX14 Rabbit Polyclonal Antibody
蛋白名称
Inactive serine/threonine-protein kinase TEX14 (Protein kinase-like protein SgK307) (Sugen kinase 307) (Testis-expressed sequence 14) (Testis-expressed sequence 14 protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56155
Human Swissprot No.
Q8IWB6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8IWB6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83560
Mouse Swissprot No.
Q7M6U3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q7M6U3/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/F1M5M3/entry
特异性
This antibody detects endogenous levels of TEX14 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expression restricted to testis.
细胞定位
Cytoplasm . Midbody . Chromosome, centromere, kinetochore . Detected in the intercellular bridges that connect male germ cell daughter cells after cell division. .
功能
Required both for the formation of intercellular bridges during meiosis and for kinetochore-microtubule attachment during mitosis. Intercellular bridges are evolutionarily conserved structures that connect differentiating germ cells and are required for spermatogenesis and male fertility. Acts by promoting the conversion of midbodies into intercellular bridges via its interaction with CEP55: interaction with CEP55 inhibits the interaction between CEP55 and PDCD6IP/ALIX and TSG101, blocking cell abscission and leading to transform midbodies into intercellular bridges. Also plays a role during mitosis: recruited to kinetochores by PLK1 during early mitosis and regulates the maturation of the outer kinetochores and microtubule attachment. Has no protein kinase activity in vitro (By similarity).
