产品名称
FGD5 Rabbit Polyclonal Antibody
蛋白名称
FYVE, RhoGEF and PH domain-containing protein 5 (Zinc finger FYVE domain-containing protein 23)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=152273
Human Swissprot No.
Q6ZNL6
Human Swissprot Link
https://www.uniprot.org/uniprot/Q6ZNL6
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=232237
Mouse Swissprot No.
Q80UZ0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80UZ0/entry
特异性
This antibody detects endogenous levels of FGD5 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in endothelial cells (at protein level).
细胞定位
Cytoplasm, cytoskeleton . Cell projection, ruffle membrane . Endoplasmic reticulum . Golgi apparatus . Early endosome . In peripheral membrane ruffles, colocolizes with F-actin. In confluent HUVECs, detected at cell-cell-contact sites where it colocalizes with vascular endothelial cadherin/CDH5.
功能
Activates CDC42, a member of the Ras-like family of Rho- and Rac proteins, by exchanging bound GDP for free GTP. Mediates VEGF-induced CDC42 activation. May regulate proangiogenic action of VEGF in vascular endothelial cells, including network formation, directional movement and proliferation. May play a role in regulating the actin cytoskeleton and cell shape.
