产品名称
AGTRAP Rabbit Polyclonal Antibody
蛋白名称
Type-1 angiotensin II receptor-associated protein (AT1 receptor-associated protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=57085
Human Swissprot No.
Q6RW13
Human Swissprot Link
https://www.uniprot.org/uniprot/Q6RW13
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11610
Mouse Swissprot No.
Q9WVK0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WVK0/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=298646
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q642A2/entry
特异性
This antibody detects endogenous levels of AGTRAP at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitous but more abundant in kidney, heart, pancreas and thyroid.
细胞定位
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Golgi apparatus membrane ; Multi-pass membrane protein . Cytoplasmic vesicle membrane ; Multi-pass membrane protein . Present in perinuclear vesicular membranes, Endoplasmic reticulum, Golgi and endocytic vesicles.
功能
Appears to be a negative regulator of type-1 angiotensin II receptor-mediated signaling by regulating receptor internalization as well as mechanism of receptor desensitization such as phosphorylation. Induces also a decrease in cell proliferation and angiotensin II-stimulated transcriptional activity.
