产品名称
RBM15B Rabbit Polyclonal Antibody
蛋白名称
Putative RNA-binding protein 15B (One-twenty two protein 3) (HuOTT3) (RNA-binding motif protein 15B)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=29890
Human Swissprot No.
Q8NDT2
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8NDT2
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=109095
Mouse Swissprot No.
Q6PHZ5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6PHZ5/entry
特异性
This antibody detects endogenous levels of RBM15B at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed.
细胞定位
Nucleus, nucleoplasm . Nucleus speckle . Nucleus envelope . Colocalizes with BMLF1 in the nucleus. Localized in the nucleoplasm with a granular staining pattern and excluded from the nucleoli. .
功能
RNA-binding protein that acts as a key regulator of N6-methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA . Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing . Plays a key role in m6A methylation, possibly by binding target RNAs and recruiting the WMM complex . Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruiting the WMM complex, which mediates m6A methylation, leading to target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist . Functions in the regulation of alternative or illicit splicing, possibly by regulating m6A methylation . Inhibits pre-mRNA splicing . Also functions as a mRNA export factor by acting as a cofactor for the nuclear export receptor NXF1 .
