产品名称
GLRA1 Rabbit Polyclonal Antibody
蛋白名称
Glycine receptor subunit alpha-1 (Glycine receptor 48 kDa subunit) (Glycine receptor strychnine-binding subunit)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=2741
Human Swissprot No.
P23415
Human Swissprot Link
https://www.uniprot.org/uniprot/P23415
Mouse Swissprot No.
Q64018
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q64018/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=25674
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P07727/entry
特异性
This antibody detects endogenous levels of GLRA1 at Human,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell junction, synapse . Perikaryon . Cell projection, dendrite . Cell membrane ; Multi-pass membrane protein .
功能
Glycine receptors are ligand-gated chloride channels . Channel opening is triggered by extracellular glycine . Channel opening is also triggered by taurine and beta-alanine . Channel characteristics depend on the subunit composition; heteropentameric channels are activated by lower glycine levels and display faster desensitization . Plays an important role in the down-regulation of neuronal excitability . Contributes to the generation of inhibitory postsynaptic currents . Channel activity is potentiated by ethanol . Potentiation of channel activity by intoxicating levels of ethanol contribute to the sedative effects of ethanol (By similarity).
