产品名称
SEC13 Rabbit Polyclonal Antibody
基因名称
SEC13 D3S1231E SEC13L1 SEC13R
蛋白名称
Protein SEC13 homolog (SEC13-like protein 1) (SEC13-related protein)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=6396
Human Swissprot No.
P55735
Human Swissprot Link
https://www.uniprot.org/uniprot/P55735
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=110379
Mouse Swissprot No.
Q9D1M0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9D1M0/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=297522
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5XFW8/entry
特异性
This antibody detects endogenous levels of SEC13 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasmic vesicle, COPII-coated vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Nucleus, nuclear pore complex . Lysosome membrane . In interphase, localizes at both sides of the NPC. .
功能
Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of COPII-coated vesicles . Required for the exit of adipsin (CFD/ADN), an adipocyte-secreted protein from the endoplasmic reticulum (By similarity). ; As a component of the GATOR subcomplex GATOR2, functions within the amino acid-sensing branch of the TORC1 signaling pathway. Indirectly activates mTORC1 and the TORC1 signaling pathway through the inhibition of the GATOR1 subcomplex . It is negatively regulated by the upstream amino acid sensors SESN2 and CASTOR1 .
