产品名称
GNDS Rabbit Polyclonal Antibody
蛋白名称
Ral guanine nucleotide dissociation stimulator (RalGDS) (Ral guanine nucleotide exchange factor) (RalGEF)
存储缓冲液
Liquid in PBS containing 50% glycerol, and 0.02% New type preservative N.
Human Swissprot No.
Q12967
Human Swissprot Link
https://www.uniprot.org/uniprotkb/Q12967/entry
Mouse Swissprot No.
Q03385
Mouse Swissprot Link
http://www.uniprot.org/uniprot/Q03385
Rat Swissprot Link
http://www.uniprot.org/uniprot/O54941Q03386
免疫原
Synthesized peptide derived from human protein . at AA range: 130-210
特异性
GNDS Polyclonal Antibody detects endogenous levels of protein.
稀释度
WB 1:500-2000 ELISA 1:5000-20000
宿主
Polyclonal, Rabbit,IgG
背景介绍
Guanine nucleotide dissociation stimulators (GDSs, or exchange factors), such as RALGDS, are effectors of Ras-related GTPases (see MIM 190020) that participate in signaling for a variety of cellular processes.[supplied by OMIM, Nov 2010],
组织表达
Brain,Epithelium,Placenta,Primary B-Cells,Spleen,Thalamus,
细胞定位
Cytoplasm . Nucleus . Localizes mainly in the peripheral region of the cytoplasmic membrane in oocytes and in preimplantation embryos until the 8-cell stage. Between the late 1-cell and the early 2-cell stages, nuclear localization becomes stronger. After the 4-cell stage, not detected in the nucleus. .
信号通路
Pathways in cancer;Colorectal cancer;Pancreatic cancer;
功能
domain:The Ras-associating domain interacts with Ras.,function:Stimulates the dissociation of GDP from the Ras-related RalA and RalB GTPases which allows GTP binding and activation of the GTPases. Interacts and acts as an effector molecule for R-Ras, H-Ras, K-Ras, and Rap.,similarity:Contains 1 N-terminal Ras-GEF domain.,similarity:Contains 1 Ras-associating domain.,similarity:Contains 1 Ras-GEF domain.,subunit:Interacts with RIT1 and RIT2.,
纯化
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
