产品名称
TRIM9 Rabbit Polyclonal Antibody
基因名称
TRIM9 KIAA0282 RNF91
蛋白名称
E3 ubiquitin-protein ligase TRIM9 (EC 6.3.2.-) (RING finger protein 91) (Tripartite motif-containing protein 9)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=114088
Human Swissprot No.
Q9C026
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9C026
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=94090
Mouse Swissprot No.
Q8C7M3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8C7M3/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=155812
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q91ZY8/entry
特异性
This antibody detects endogenous levels of TRIM9 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Brain. Highly expressed in the cerebral cortex (at protein level). Severely decreased in the affected brain areas in Parkinson disease and dementia with Lewy bodies.
细胞定位
Cytoplasm . Cell projection, dendrite . Cytoplasmic vesicle, secretory vesicle, synaptic vesicle . Cell junction, synapse . Cytoplasm, cytoskeleton . Enriched at synaptic terminals where it exists in a soluble form and a synaptic vesicle-associated form. Associated with the cytoskeleton (By similarity). Found in proximal dendrites of pyramidal neurons in the cerebral cortex and hippocampus, and Purkinje cells in the cerebellum (PubMed:20085810). .
功能
E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.
