产品名称
HBS1L Rabbit Polyclonal Antibody
蛋白名称
HBS1-like protein (ERFS)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10767
Human Swissprot No.
Q9Y450
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9Y450
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=56422
Mouse Swissprot No.
Q69ZS7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q69ZS7/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=293408
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6AXM7/entry
特异性
This antibody detects endogenous levels of HBS1L at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Detected in heart, brain, placenta, liver, muscle, kidney and pancreas.
细胞定位
[Isoform 2]: Cytoplasm .
功能
Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway . In the presence of ABCE1 and PELO, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes . Together with PELO and in presence of ABCE1, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs; this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway . ; [Isoform 2]: Facilitates the association of the exosome complex with the SKI complex.
