产品名称
RAI14 Rabbit Polyclonal Antibody
基因名称
RAI14 KIAA1334 NORPEG
蛋白名称
Ankycorbin (Ankyrin repeat and coiled-coil structure-containing protein) (Novel retinal pigment epithelial cell protein) (Retinoic acid-induced protein 14)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=26064
Human Swissprot No.
Q9P0K7
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9P0K7
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=75646
Mouse Swissprot No.
Q9EP71
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9EP71/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=294804
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5U312/entry
特异性
This antibody detects endogenous levels of RAI14 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in placenta, muscle, kidney and testis. Moderately expressed in heart, brain, lung, liver and intestine. Isoform 2 is widely expressed and expressed in fetal and adult testes, and spermatozoa.
细胞定位
Cytoplasm, cytoskeleton . Cytoplasm, cytoskeleton, stress fiber . Cytoplasm, cell cortex . Cell junction . Nucleus . Associated with the cortical actin cytoskeleton structures in terminal web and cell-cell adhesion sites (By similarity). Highly expressed at the ectoplasmic specialization, an actin-rich cell junction specific to the testis (By similarity). Predominantly nuclear in nonconfluent cells (PubMed:16729964). .
功能
Plays a role in actin regulation at the ectoplasmic specialization, a type of cell junction specific to testis. Important for establishment of sperm polarity and normal spermatid adhesion. May also promote integrity of Sertoli cell tight junctions at the blood-testis barrier.
