产品名称
PRICKLE1 Rabbit Polyclonal Antibody
蛋白名称
Prickle-like protein 1 (REST/NRSF-interacting LIM domain protein 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=144165
Human Swissprot No.
Q96MT3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q96MT3
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=106042
Mouse Swissprot No.
Q3U5C7
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3U5C7/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q71QF9/entry
特异性
This antibody detects endogenous levels of PRICKLE1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed at highest levels in placenta and at lower levels in lung, liver, kidney and pancreas. Expressed in thalamus, hippocampus, cerebral cortex, and cerebellum (in neurons rather than glia).
细胞定位
Nucleus membrane . Cytoplasm, cytosol . A smaller amount is detected in the cytosol.
功能
Involved in the planar cell polarity pathway that controls convergent extension during gastrulation and neural tube closure. Convergent extension is a complex morphogenetic process during which cells elongate, move mediolaterally, and intercalate between neighboring cells, leading to convergence toward the mediolateral axis and extension along the anteroposterior axis. Necessary for nuclear localization of REST. May serve as nuclear receptor.
