产品名称
RBPMS Rabbit Polyclonal Antibody
蛋白名称
RNA-binding protein with multiple splicing (RBP-MS) (Heart and RRM expressed sequence) (Hermes)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11030
Human Swissprot No.
Q93062
Human Swissprot Link
https://www.uniprot.org/uniprot/Q93062
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=19663
Mouse Swissprot No.
Q9WVB0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WVB0/entry
特异性
This antibody detects endogenous levels of RBPMS at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed, at various levels depending on the isoform and the tissue.
细胞定位
Nucleus . Cytoplasm . Cytoplasm, P-body . Translocates into cytoplasmic stress granules that probably correspond to P-bodies in response to oxidative stress. .
功能
Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins . Binds to poly(A) RNA .
