产品名称
AFAP1 Rabbit Polyclonal Antibody
蛋白名称
Actin filament-associated protein 1 (110 kDa actin filament-associated protein) (AFAP-110)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=60312
Human Swissprot No.
Q8N556
Human Swissprot Link
https://www.uniprot.org/uniprot/Q8N556
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=70292
Mouse Swissprot No.
Q80YS6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q80YS6/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=140935
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q8VH46/entry
特异性
This antibody detects endogenous levels of AFAP1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Low expression in normal breast epithelial cell line MCF-10A and in tumorigenic breast cancer cell lines MCF-7, T-47D and ZR-75-1. Highly expressed in the invasive breast cancer cell lines MDA-MB-231 and MDA-MB-435. Overexpressed in prostate carcinoma.
细胞定位
Cytoplasm, cytoskeleton, stress fiber .
功能
Can cross-link actin filaments into both network and bundle structures (By similarity). May modulate changes in actin filament integrity and induce lamellipodia formation. May function as an adapter molecule that links other proteins, such as SRC and PKC to the actin cytoskeleton. Seems to play a role in the development and progression of prostate adenocarcinoma by regulating cell-matrix adhesions and migration in the cancer cells.
