产品名称
TRIM14 Rabbit Polyclonal Antibody
蛋白名称
Tripartite motif-containing protein 14
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9830
Human Swissprot No.
Q14142
Human Swissprot Link
https://www.uniprot.org/uniprot/Q14142
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=74735
Mouse Swissprot No.
Q8BVW3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q8BVW3/entry
特异性
This antibody detects endogenous levels of TRIM14 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highest expression in liver; undetectable in skeletal muscle.
细胞定位
Mitochondrion outer membrane . Cytoplasmic vesicle, phagosome .
功能
Plays an essential role in the innate immune defense against viruses and bacteria . Facilitates the type I IFN response by interacting with MAVS at the outer mitochondria membrane and thereby recruiting NF-kappa-B essential modulator IKBKG/NEMO to the MAVS signalosome, leading to the activation of both the IFN regulatory factor 3/IRF3 and NF-kappa-B pathways . Positively regulates the CGAS-induced type I interferon signaling pathway by stabilizing CGAS and inhibiting its autophagic degradation . Acts as a scaffold between TBK1 and STAT3 to promote phosphorylation of STAT3 and resolve interferon-stimulated gene (ISG) expression . Inhibits the transcriptional activity of SPI1 in a dose-dependent manner (By similarity).
