产品名称
NDOR1/NR1 Rabbit Polyclonal Antibody
蛋白名称
NADPH-dependent diflavin oxidoreductase 1 (EC 1.6.-.-) (NADPH-dependent FMN and FAD-containing oxidoreductase) (Novel reductase 1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27158
Human Swissprot No.
Q9UHB4
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UHB4
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=78797
Mouse Swissprot No.
A2AI05
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/A2AI05/entry
特异性
This antibody detects endogenous levels of NDOR1/NR1 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Low expression in brain, heart, kidney, pancreas, prostate and skeletal muscle. Highest levels in the placenta. Expressed in cancer cell lines including promyelocytic leukemia, HeLaS3, chronic myelagenous leukemia, lymphoblastic leukemia, Burkitt's lymphoma, colorectal adenocarcinoma, lung carcinoma, and melanoma G-361.
细胞定位
Cytoplasm, perinuclear region . Concentrated in perinuclear structure. .
功能
NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery . Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery . In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins . It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair . In vitro can fully activate methionine synthase/MTR in the presence of soluble cytochrome b5/CYB5A .
