产品名称
NSFL1C Rabbit Polyclonal Antibody
蛋白名称
NSFL1 cofactor p47 (UBX domain-containing protein 2C) (p97 cofactor p47)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55968
Human Swissprot No.
Q9UNZ2
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UNZ2
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=386649
Mouse Swissprot No.
Q9CZ44
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CZ44/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=83809
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/O35987/entry
特异性
This antibody detects endogenous levels of NSFL1C at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Nucleus . Golgi apparatus, Golgi stack . Chromosome . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Predominantly nuclear in interphase cells. Bound to the axial elements of sex chromosomes in pachytene spermatocytes. A small proportion of the protein is cytoplasmic, associated with Golgi stacks. Localizes to centrosome during mitotic prophase and metaphase. .
功能
Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) . Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase . Also, regulates spindle orientation during mitosis .
