产品名称
COLEC11 Rabbit Polyclonal Antibody
基因名称
COLEC11 UNQ596/PRO1182
蛋白名称
Collectin-11 (Collectin kidney protein 1) (CL-K1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=78989
Human Swissprot No.
Q9BWP8
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9BWP8
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=71693
Mouse Swissprot No.
Q3SXB8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q3SXB8/entry
特异性
This antibody detects endogenous levels of COLEC11 at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitous (PubMed:17179669). Detected in adrenal gland, kidney, liver, ovaries and testis (at protein level) (PubMed:20956340).
功能
Lectin that plays a role in innate immunity, apoptosis and embryogenesis . Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope . Primarily recognizes the terminal disaccharide of the glycan . Also recognizes a subset of fucosylated glycans and lipopolysaccharides . Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1 . Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding (Probable). Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis .
