产品名称
DNAJB9 Rabbit Polyclonal Antibody
基因名称
DNAJB9 MDG1 UNQ743/PRO1471
蛋白名称
DnaJ homolog subfamily B member 9 (Microvascular endothelial differentiation gene 1 protein) (Mdg-1)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=4189
Human Swissprot No.
Q9UBS3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UBS3
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=27362
Mouse Swissprot No.
Q9QYI6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QYI6/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24908
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/P97554/entry
特异性
This antibody detects endogenous levels of DNAJB9 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Widely expressed. Expressed at highest level in the liver, placenta and kidney (PubMed:11836248).
细胞定位
Endoplasmic reticulum lumen .
功能
Co-chaperone for Hsp70 protein HSPA5/BiP that acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (By similarity). J domain-containing co-chaperones stimulate the ATPase activity of Hsp70 proteins and are required for efficient substrate recognition by Hsp70 proteins . In the unstressed endoplasmic reticulum, interacts with the luminal region of ERN1/IRE1 and selectively recruits HSPA5/BiP: HSPA5/BiP disrupts the dimerization of the active ERN1/IRE1 luminal region, thereby inactivating ERN1/IRE1 (By similarity). Also involved in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins. Required for survival of B-cell progenitors and normal antibody production (By similarity).
