产品名称
RENALASE Rabbit Polyclonal Antibody
蛋白名称
Renalase (EC 1.4.-.-) (Monoamine oxidase-C) (MAO-C)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=55328
Human Swissprot No.
Q5VYX0
Human Swissprot Link
https://www.uniprot.org/uniprot/Q5VYX0
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=67795
Mouse Swissprot No.
A7RDN6
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/A7RDN6/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=361751
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5U2W9/entry
特异性
This antibody detects endogenous levels of RENALASE at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Secreted into the blood by the kidney. Highly expressed in the kidney, expressed at lower level in heart, skeletal muscle and small intestine. Its plasma concentration is markedly reduced in patients with end-stage renal disease, as compared with healthy subjects.
功能
Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis.
