产品名称
PACSIN2 Rabbit Polyclonal Antibody
蛋白名称
Protein kinase C and casein kinase substrate in neurons protein 2
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11252
Human Swissprot No.
Q9UNF0
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9UNF0
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23970
Mouse Swissprot No.
Q9WVE8
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WVE8/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=124461
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9QY17/entry
特异性
This antibody detects endogenous levels of PACSIN2 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton . Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Early endosome. Recycling endosome membrane. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection . Membrane, caveola . Detected at the neck of flask-shaped caveolae. Localization to tubular recycling endosomes probably requires interaction with MICALL1 and EHD1.
功能
Regulates the morphogenesis and endocytosis of caveolae (By similarity). Lipid-binding protein that is able to promote the tubulation of the phosphatidic acid-containing membranes it preferentially binds. Plays a role in intracellular vesicle-mediated transport. Involved in the endocytosis of cell-surface receptors like the EGF receptor, contributing to its internalization in the absence of EGF stimulus. ; (Microbial infection) Specifically enhances the efficiency of HIV-1 virion spread by cell-to-cell transfer . Also promotes the protrusion engulfment during cell-to-cell spread of bacterial pathogens like Listeria monocytogenes . Involved in lipid droplet formation, which is important for HCV virion assembly .
