产品名称
WDR45 Rabbit Polyclonal Antibody
基因名称
WDR45 WDRX1 WDRXI4 WIPI4 JM5
蛋白名称
WD repeat domain phosphoinositide-interacting protein 4 (WIPI-4) (WD repeat-containing protein 45)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=11152
Human Swissprot No.
Q9Y484
Human Swissprot Link
https://www.uniprot.org/uniprot/Q9Y484
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=54636
Mouse Swissprot No.
Q91VM3
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q91VM3/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=302559
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q5U2Y0/entry
特异性
This antibody detects endogenous levels of WDR45 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed, with high expression in skeletal muscle and heart. Weakly expressed in liver and placenta. Expression is down-regulated in pancreatic and in kidney tumors.
细胞定位
Preautophagosomal structure . Cytoplasm . Diffusely localized in the cytoplasm under nutrient-rich conditions. Localizes to autophagic structures during starvation-induced autophagy. .
功能
Component of the autophagy machinery that controls the major intracellular degradation process by which cytoplasmic materials are packaged into autophagosomes and delivered to lysosomes for degradation . Binds phosphatidylinositol 3-phosphate (PtdIns3P) . Activated by the STK11/AMPK signaling pathway upon starvation, WDR45 is involved in autophagosome assembly downstream of WIPI2, regulating the size of forming autophagosomes . Together with WIPI1, promotes ATG2 (ATG2A or ATG2B)-mediated lipid transfer by enhancing ATG2-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes . Probably recruited to membranes through its PtdIns3P activity .
