产品名称
GLRX3 Rabbit Polyclonal Antibody
基因名称
GLRX3 PICOT TXNL2 HUSSY-22
蛋白名称
Glutaredoxin-3 (PKC-interacting cousin of thioredoxin) (PICOT) (PKC-theta-interacting protein) (PKCq-interacting protein) (Thioredoxin-like protein 2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=10539
Human Swissprot No.
O76003
Human Swissprot Link
https://www.uniprot.org/uniprot/O76003
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=30926
Mouse Swissprot No.
Q9CQM9
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9CQM9/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=58815
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9JLZ1/entry
特异性
This antibody detects endogenous levels of GLRX3 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Expressed in heart, spleen, testis and, to a lower extent, in thymus and peripheral blood leukocytes. Weakly expressed in lung, placenta, colon and small intestine.
细胞定位
Cytoplasm, cytosol . Cytoplasm, cell cortex . Cytoplasm, myofibril, sarcomere, Z line . Under the plasma membrane (By similarity). After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area (By similarity). In the Z line, found associated with CSRP3 (By similarity). .
功能
Together with BOLA2, acts as a cytosolic iron-sulfur (Fe-S) cluster assembly factor that facilitates [2Fe-2S] cluster insertion into a subset of cytosolic proteins . Acts as a critical negative regulator of cardiac hypertrophy and a positive inotropic regulator (By similarity). Required for hemoglobin maturation . Does not possess any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity.
