产品名称
VTCN1 Rabbit Polyclonal Antibody
基因名称
VTCN1 B7H4 UNQ659/PRO1291
蛋白名称
V-set domain-containing T-cell activation inhibitor 1 (B7h.5) (Immune costimulatory protein B7-H4) (Protein B7S1) (T-cell costimulatory molecule B7x)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=79679
Human Swissprot No.
Q7Z7D3
Human Swissprot Link
https://www.uniprot.org/uniprot/Q7Z7D3
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=242122
Mouse Swissprot No.
Q7TSP5
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q7TSP5/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=295322
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q501W4/entry
特异性
This antibody detects endogenous levels of VTCN1 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Overexpressed in breast, ovarian, endometrial, renal cell (RCC) and non-small-cell lung cancers (NSCLC). Expressed on activated T- and B-cells, monocytes and dendritic cells, but not expressed in most normal tissues (at protein level). Widely expressed, including in kidney, liver, lung, ovary, placenta, spleen and testis.
细胞定位
Cell membrane ; Single-pass type I membrane protein . Expressed at the cell surface. A soluble form has also been detected. .
功能
Negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the suppression of tumor-associated antigen-specific T-cell immunity. Involved in promoting epithelial cell transformation.
