产品名称
ATG2A Rabbit Polyclonal Antibody
蛋白名称
Autophagy-related protein 2 homolog A
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=23130
Human Swissprot No.
Q2TAZ0
Human Swissprot Link
https://www.uniprot.org/uniprot/Q2TAZ0
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=329015
Mouse Swissprot No.
Q6P4T0
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q6P4T0/entry
特异性
This antibody detects endogenous levels of ATG2A at Human, Mouse
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Preautophagosomal structure membrane ; Peripheral membrane protein . Lipid droplet . Endoplasmic reticulum membrane ; Peripheral membrane protein . Localizes to endoplasmic reticulum-autophagosome contact sites. .
功能
Lipid transfer protein involved in autophagosome assembly . Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion . Binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, and extracts phospholipids from the membrane source and transfers them to ATG9 (ATG9A or ATG9B) to the IM for membrane expansion . Lipid transfer activity is enhanced by WIPI1 and WDR45/WIPI4, which promote ATG2A-association with phosphatidylinositol 3-monophosphate (PI3P)-containing membranes . Also regulates lipid droplets morphology and distribution within the cell .
