产品名称
SH3BP5 Rabbit Polyclonal Antibody
蛋白名称
SH3 domain-binding protein 5 (SH3BP-5) (SH3 domain-binding protein that preferentially associates with BTK)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=9467
Human Swissprot No.
O60239
Human Swissprot Link
https://www.uniprot.org/uniprot/O60239
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=24056
Mouse Swissprot No.
Q9Z131
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/Q9Z131/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=117186
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q91Y80/entry
特异性
This antibody detects endogenous levels of SH3BP5 at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Highly expressed in testis and ovaries. It is also expressed in a variety of tissues including spleen, lymph node, thymus, bone marrow, fetal liver, colon, small intestine and prostate.
细胞定位
Cytoplasmic vesicle membrane ; Peripheral membrane protein . Mitochondrion . Colocalizes with RAB11A on cytoplasmic vesicle membranes. .
功能
Functions as guanine nucleotide exchange factor (GEF) with specificity for RAB11A and RAB25 . Inhibits the auto- and transphosphorylation activity of BTK. Plays a negative regulatory role in BTK-related cytoplasmic signaling in B-cells. May be involved in BCR-induced apoptotic cell death.
