产品名称
DOM3Z Rabbit Polyclonal Antibody
蛋白名称
Protein Dom3Z (Dom-3 homolog Z)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=1797
Human Swissprot No.
O77932
Human Swissprot Link
https://www.uniprot.org/uniprot/O77932
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=112403
Mouse Swissprot No.
O70348
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/O70348/entry
Rat Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=361799
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q6MG77/entry
特异性
This antibody detects endogenous levels of DOM3Z at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
组织表达
Ubiquitously expressed.
功能
Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA . The NAD-cap is present at the 5'-end of some RNAs and snoRNAs . In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay . Preferentially acts on NAD-capped transcripts in response to environmental stress . Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation (By similarity). Specifically degrades pre-mRNAs with a defective 5'-end m7G cap and is part of a pre-mRNA capping quality control (By similarity). Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) . In contrast to canonical decapping enzymes DCP2 and NUDT16, which cleave the cap within the triphosphate linkage, the decapping activity releases the entire cap structure GpppN and a 5'-end monophosphate RNA (By similarity). Also has 5'-3' exoribonuclease activities: The 5'-end monophosphate RNA is then degraded by the 5'-3' exoribonuclease activity, enabling this enzyme to decap and degrade incompletely capped mRNAs . Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (By similarity). Exhibits decapping activity towards FAD-capped RNAs . Exhibits decapping activity towards dpCoA-capped RNAs in vitro (By similarity).
