产品名称
KIF2A Rabbit Polyclonal Antibody
蛋白名称
Kinesin-like protein KIF2A (Kinesin-2) (hK2)
存储缓冲液
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% New type preservative N.
Human Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=3796
Human Swissprot No.
O00139
Human Swissprot Link
https://www.uniprot.org/uniprot/O00139
Mouse Gene Link
http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&term=16563
Mouse Swissprot No.
P28740
Mouse Swissprot Link
https://www.uniprot.org/uniprotkb/P28740/entry
Rat Swissprot Link
https://www.uniprot.org/uniprotkb/Q9WV63/entry
特异性
This antibody detects endogenous levels of KIF2A at Human, Mouse,Rat
运输及保存条件
-15°C to -25°C/1 year(Do not lower than -25°C)
细胞定位
Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, spindle pole. Cytoplasm, cytoskeleton, spindle. Localized to the spindle microtubules and spindle poles from prophase to metaphase. Efficient targeting to spindle microtubules and spindle poles requires the kinase activity of PLK1. Recruited to mitotic spindles by interaction with PSRC1.
功能
Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity.
